Abstract
Seven alkaloids of indole nucleus were isolated from Rhazya stricta (Apocynaceae). Two of which are new epi-rhazyaminine (1) and 20-epi-sitsirikine (2), while the rest are known; eburenine (3), strictamine (4), (16 R)-E-isositsirikine (5), antirhine (6), and strictanol (7). The chemical structures of the isolated compounds were elucidated by interpretation of the obtained spectral data 1D (1H, 13C and DEPT) and 2D (COSY, HSQC, HMBC and NOESY) NMR, UV, IR and MS. Compounds 1-7 were tested against three cancer cell lines; human colorectal carcinoma (HCT-116), prostate cancer (PC-3), human hepatocellular liver carcinoma (HepG2) and normal adult African green monkey kidney (VERO).
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