Abstract
As part of our continual efforts to exploit ‘Tujia Ethnomedicine’ for their pharmacophoric functionalities, we herein investigated Kadsura heteroclita collected from a deep Wulin mountain area in northern Hunan province. The current study resulted in the isolation of three new sesquiterpenes: 6α,9α,15-trihydroxycadinan-4-en-3-one (1), (+)-3,11,12-trihydroxycalamenene (2), (–)-3,10,11,12-tetrahydroxy-calamenene (3), along with four known sesquiterpenes (4–7), and a cytochalasin H (8). Their chemical structures were elucidated by 1D-, and 2D-NMR spectroscopy, and HRESI-MS, CD spectrometry. The antioxidant, and cytotoxic activities of the compounds were evaluated. Compound 8 exhibited a strong antioxidant effect with an IC50 value of 3.67 µM on isolated human polymorphonuclear cells or neutrophils.
Highlights
In the last few decades, phytochemical work on the family Schisandraceae has resulted in a seminal contribution to novel structural frameworks for triterpenoidal skeletons [1,2,3,4]
Compound 3 (–)-3,10,11,12-tetrahydroxycalamenene was isolated as white amorphous powder and its molecular formula C15H22O4 was established based on its HRESIMS data
According to 3D molecular model and coupling constant of H-7, the 1,2-isopropanediol group and 10-OH are in an axial position, which may be induced by the Van der
Summary
In the last few decades, phytochemical work on the family Schisandraceae has resulted in a seminal contribution to novel structural frameworks for triterpenoidal skeletons [1,2,3,4]. Molecules 2019, 24, x province, the stems of K. heteroclita are used to treat traumatic injuries and rheumatoid arthritis by. Stems of K. heteroclita used to people treat traumatic injuries and they rheumatoid one of the Chinesethe ethnic minorities known are as the. Tujia people [14,15] They the stems of K. heteroclita as “Xue Tong” which means “circulating the blood system”, which is used named the stems of. Which means “circulating the blood system”, which to treat blood related diseases [16] These features triggered our research enthusiasm to explore the is used tometabolites treat bloodfrom related [16].
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