Abstract
Oxazine compounds have drew the attention of many researchers to find different approaches to the synthesis of this type of compounds according to the success of their use in a wide range of pharmaceutical application during the last decades .It is also for the difference reactivity of these analogues is exhaustively depicted and illustrates the rich versatility of this class of starting material. They proved to have most of actions of a combination of other drugs. We are herein investigate the synthesis of ethyl aryloxy acetate(S1-6) from the reaction of the corresponding ethyl bromo acetate with aryl phenols .These intermediates were cyclized with antharanilic acid affording the titled compounds
Highlights
The chemistry of Oxazine becomes an important branch of heterocyclic compounds not just as synthetic intermediates and due to the wide spectrum application of this type of compounds in medicine
Oxazine compounds have drew the attention of many researchers to find different approaches to the synthesis of this type of compounds according to the success of their use in a wide range of pharmaceutical application during the last decades .It is for the difference reactivity of these analogues is exhaustively depicted and illustrates the rich versatility of this class of starting material
Piste have reported the preparation of some 1,3- oxazine compounds from phenols and aromatic aldehydes in methanolic ammonia and have studied their anti-microbial activity against two gram positive and two gram negative bacteria .Antifungal activity was screened against Candidaalbicans, Aspergillus niger [7]
Summary
The chemistry of Oxazine becomes an important branch of heterocyclic compounds not just as synthetic intermediates and due to the wide spectrum application of this type of compounds in medicine. These intermediates were cyclized with antharanilic acid affording the titled compounds.
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