Abstract
Abstract The Horner-Wadsworth-Emmons reaction of both 1 (Still's reagent) and 2 (Ando's reagent) with aldehydes was studied. Tris[2-(2-methoxyethoxy)ethyl]amine (TDA-1) was shown to be an efficient additive when the reaction was performed in THF at −78 °C. Selectivities close to 95% were obtained in the condensation of 1 with aromatic aldehydes. The use of a 5-fold excess of 18C6 in this reaction had already been reported. However, we have defined conditions in which only catalytic amounts are required.
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