Abstract
Four new special compounds with character of an iriflophene unit and a flavonoid unit connecting via a furan ring were isolated from the roots of Sedum aizoon L. Their corresponding structures were elucidated on the basis of spectroscopic analysis. The in vitro anti-proliferative activities against BXPC-3, A549, and MCF-7 tumor cell lines were evaluated. Compounds 3 and 4 exhibited moderate cytotoxic activities with IC50 ranging from 24.84 to 37.22 μmol L−1, which was capable for further drug exploration.
Highlights
Sedum aizoon L., is an endemic plant, named ‘jingtiansanqi’ in folk medicine
Four new special adducts of iriflophene and flavonoids connecting via a furan ring were discovered
The dimers of iriflophene and flavonoids were reported for the first time, which enriched the chemical constituents of the Crassulaceae family
Summary
Sedum aizoon L., is an endemic plant, named ‘jingtiansanqi’ in folk medicine It is distributed in in Japan, North Korea, Mongolia, and China. The whole plant is used as a traditional medicine to. The whole plant is used as a traditional medicine to treat treat traumatism, hemorrhage, palpitation, and neurasthenia [1,2,3]. The phytochemical traumatism, hemorrhage, palpitation, and neurasthenia [1,2,3]. The phytochemical constituents of Sedum aizoon L. have been extensively reported but only restricted to the aerial part [4,5,6,7,8,9]
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