Abstract
In recent years, there has been tremendous progress in uncovering the molecular, cellular and systemic factors that give rise to neuronal death following acute neurological insults. This has fuelled a burgeoning interest in the use of gene transfer techniques to protect neurons from such insults. This review describes these gene therapy strategies from the perspective of the biology of neuronal death, considering which steps in the cell death cascades have been successfully targeted in pre-clinical studies, and how this research might be applied to the clinic.
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