Abstract
A new melatonin analogue 6-hydroxy-N-acetyl-β-oxotryptamine (1) was isolated from the marine-derived fungus Penicillium sp. KMM 4672. It is the second case of melatonin-related compounds isolation from microfilamentous fungi. The neuroprotective activities of this metabolite, as well as 3-methylorsellinic acid (2) and 8-methoxy-3,5-dimethylisochroman-6-ol (3) from Penicillium sp. KMM 4672, candidusin A (4) and 4″-dehydroxycandidusin A (5) from Aspergillus sp. KMM 4676, and diketopiperazine mactanamide (6) from Aspergillus flocculosus, were investigated in the 6-hydroxydopamine (6-OHDA)- and paraquat (PQ)-induced Parkinson’s disease (PD) cell models. All of them protected Neuro2a cells against the damaging influence of 6-OHDA to varying degrees. This effect may be realized via a reactive oxygen species (ROS) scavenging pathway. The new melatonin analogue more effectively protected Neuro2A cells against the 6-OHDA-induced neuronal death, in comparison with melatonin, as well as against the PQ-induced neurotoxicity. Dehydroxylation at C-3″ and C-4″ significantly increased free radical scavenging and neuroprotective activity of candidusin-related p-terphenyl polyketides in both the 6-OHDA- and PQ-induced PD models.
Highlights
Parkinson’s disease is one of the most common age-related motoric neurodegenerative diseases, regardless of countries and regions
These findings show the requirement of using antioxidants as a therapeutic intervention in Parkinson’s disease (PD) in addition to other protective agents [2]
We described the isolation and identification of new alkaloid and known polyketides from the marine fungus Penicillium sp
Summary
Parkinson’s disease is one of the most common age-related motoric neurodegenerative diseases, regardless of countries and regions. This disease is characterized clinically by resting tremor, bradykinesia, rigidity, and postural instability, that significantly worsen the life quality of patients [1]. Some of the studies show that ROS can cause mitochondrial dysfunction and activation of apoptosis-related death signaling, which lead to neuronal cell death. These findings show the requirement of using antioxidants as a therapeutic intervention in PD in addition to other protective agents [2]. One of the most popular cell-free tests in natural product antioxidant studies is the
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