Abstract
The term gluten-related disorders (GRD) refers to a spectrum of diverse immune-mediated diseases triggered by the ingestion of gluten – the protein found in wheat, barley, and rye. Celiac disease (CD) is the most well-characterized entity, but extraintestinal manifestations are increasingly recognized. Such manifestations include skin involvement in the form of dermatitis herpetiformis (DH) and neurological dysfunction (e.g., gluten ataxia and gluten neuropathy). The recent concept of extraintestinal manifestations without enteropathy – sometimes called non-celiac gluten sensitivity (NCGS) – has emerged as part of the same spectrum, possibly with a different immune-mediated pathophysiology. In this chapter, we review the common neurological manifestations in GRD and discuss possible pathophysiological mechanisms.
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