Abstract
Two cases of cat scratch disease with associated encephalopathy involving patients in the pediatric age group have been reported. They fulfill the criteria for such a diagnosis, namely: (1) history of cat scratch or of contact with a cat; (2) regional adenopathy; (3) positive skin test with cat scratch antigen; (4) histologic picture of biopsied lymph nodes consistent with cat scratch disease plus a sterile culture obtained from the same node; (5) otherwise unexplained encephalopathic symptoms developing within 6 weeks of the appearance of adenopathy. Review of the literature and this report of two cases suggests that this disease may be sudden and severe in onset but is self-limited with benign sequelae and in most cases without residual effect. In all cases of encephalitis with associated unexplained lymphadenopathy the diagnosis of cat scratch disease should be entertained as an etiologic factor.
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