Abstract
Malignant epithelioid glioneuronal tumor is a rare high-grade, aggressive brain tumor that shows both glial and neuronal differentiation on histopathology but is not included in the current World Health Organization classification. The neuroimaging appearance is variable but may be secondary to the size of the mass and/or location of the tumor. In our series, all epithelioid glioneuronal tumors were encountered in the supratentorial space and included pineal, temporal, and extratemporal lobar cerebral hemisphere locations. When large, the tumors demonstrate cystic degeneration and necrosis, hemorrhage, contrast enhancement, and regions of low apparent diffusion coefficient scalars consistent with patterns seen with other high-grade pediatric brain tumors. The tumors also have a propensity to spread into the meninges at presentation and for distant CSF spread on follow-up imaging.
Highlights
1740 Orman Sep 2020 www.ajnr.org neurofilament protein immunostaining was performed in any case of suspected malignant glioma with unusual clinical, radiographic, and/or histologic features.[6] Neuroimaging is essential for the initial diagnosis; a systematic review of the neuroimaging findings of pediatric Malignant epithelioid glioneuronal tumor (MEGNT) has not been described.[4] The purpose of this article was to describe the CT and MR imaging features of this rare and aggressive tumor in a pediatric case series
Neuroimaging features of Malignant epithelioid glioneuronal tumor (MEGNT) were described in only a few articles in the literature with various CT and MR imaging findings.[4,6]
An unusual or necrosis or both were seen in all pineal (100%) and extratemporal finding on CT in one of our patients was an associated calvarial tumors (100%) but in none of the temporal tumors (0%). bone erosion and bone scalloping adjacent to the brain tumor, Leptomeningeal/dural extension was more frequent with extratem- which have not been previously reported with MEGNT, likely poral tumors (100%) but was not seen with temporal (0%) or pineal because most of the nonpineal tumors involved the cortical and
Summary
1740 Orman Sep 2020 www.ajnr.org neurofilament protein immunostaining was performed in any case of suspected malignant glioma with unusual clinical, radiographic, and/or histologic features.[6] Neuroimaging is essential for the initial diagnosis; a systematic review of the neuroimaging findings of pediatric MEGNT has not been described.[4] The purpose of this article was to describe the CT and MR imaging features of this rare and aggressive tumor in a pediatric case series. MEGNT is a rare aggressive brain tumor that can be encountered in both children and adults.[4,7] Neuroimaging features of MEGNT were described in only a few articles in the literature with various CT and MR imaging findings.[4,6] Varlet et al[6] reported a series of
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