Neural underpinnings of default mode network on empathy revealed by intracranial stereoelectroencephalography.

Abstract

Empathy is the ability to understand and share the feelings of others. It is fundamental to emotional intelligence and social iterations. Neuroimaging studies have demonstrated that empathy activates brain regions associated with the social cognition network. To explore the neural underpinnings of empathy revealed by stereoelectroencephalography utilizing recurrence quantification analysis (RQA). This retrospective cohort included 38 epilepsy patients with stereoelectroencephalography implantation. RQA metrics were applied to parameterize the network organization of default mode network (DMN) brain regions. The relationships between DMN, seizure burden activity, and empathy, as measured using the Interpersonal Reactivity Index, were examined using partial least-square regression and mediation analysis. RQA metrics with DMN (R2 = 0.75, PBonferroni < 0.001) and its subsystems (medial temporal subsystem: R2 = 0.53, PBonferroni < 0.001; core subsystem: R2 = 0.70, PBonferroni < 0.001; dorsal medial subsystem: R2 = 0.48, PBonferroni < 0.001) were positively correlated with empathy scores. Of 13 RQA metrics, the mean diagonal line length, entropy of the diagonal line lengths, trapping time, maximal vertical line length, and recurrence time of second type were found to be statistically higher in patient cohorts with reportedly high empathy. Furthermore, DMN characteristics (b path: F= 3.69, P= 0.04), rather than seizure burdens (direct effect: t= 0.33, P= 0.74, c'= - 0.007), mediated empathy status. The present study used various RQA metrics to parameterize the network organization of DMN and determine the neural underpinning of DMN for empathy modulation.