Abstract
AbstractPeripheral vascular resistance in anesthetized rabbits quickly increased during hemorrhagic hypotension, despite almost unchanged sympathetic nerve activity. Simultaneous measurement of blood flow to denervated and innervated kidneys showed that the acute rise of renal vascular resistance during hypotension was independent of innervation. In other animals, the left, innervated kidney was perfused with blood from either the host or a donor rabbit, by means of a pump. Renal vascular resistance invariably rose during systemic hypotension when the kidney was perfused with blood from the rabbit subjected to hemorrhage, but not when perfused with blood from a normovolemic animal. The results support the view that increased peripheral vascular resistance during the first minutes of hemorrhagic hypotension is caused by humoral agents, rather than by increased sympathetic activity.
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