Abstract
A simultaneous determination of T4 and TSH has been done on 53.000 new borns since January 1st of 1977 in the Midi-Pyrénées district. 18 cases of hypothyroïdism have been detected, an incidence of 1/2950 new borns. TSH values always were above 80 μU/ml ; T4 values are under m -2 σ in 14 cases, normal in 2 cases (8,8 and 9 μg/dl) and between -1 and -2 σ in 2 cases. A thyroid scanning with 123 iodine or 99 Tech. has shown the absence of thyroid in 8 cases, an ectopic gland in 8 cases and a thyroid in a normal position in one case. A treatment has been possible before the first month of life in each case. The average D.Q. for the seven oldest new borns (m = 11 months) is 96. The simultaneous determination of T4 and TSH is a sensitive and specific screening method for hypothyroidism. False-negative are avoided and the number of false-positive results is reduced. All cases of hypothyroidism can be detected (primary hypothyroïdism, hypothalamo-hypopituitary hypothyroïdism, TBG deficiency, etc. . .). Then, an early and certain diagnosis is made possible (T4 low and TSH increased).
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