Neonatal Immune Thrombocytopenia Due to Allo-or Autoantibodies: Clinical and Immunological Analysis of 83 Cases

Abstract

Serological and clinical data were collected in 59 cases of suspected neonatal alloimmune thrombocytopenia (NAIT) and in 24 thrombocytopenic newborn of mothers with presumed autoimmune thrombocytopenic purpura (AITP). In the NAIT group, the anti-HPA-la (anti-Zw(a), anti-Pl(AI)) and the anti-HPA-5b (anti-Br(a)) account for about 68% and 11% respectively of the serologically proven cases. The findings of a high frequency (45%) of maternal anti-HLA antibodies in the HPA-la positive group, suggests an association of NAIT and maternal HLA alloimmunisation. In the AITP group, 83% of the women had increased amounts of platelet-associated IgG (PAIgG) with a predominance of IgGl and IgG3. In one third of the cases, maternal circulating autoantibodies, mainly against GPIIb/IIIa and GPIb/IX, were found. The finding of circulating platelet autoantibodies in 16% of the HPA-la positive non-thrombocytopenic mothers makes it possible that these women are suffering from compensated AITP. In the AITP group, neither maternal platelet count, maternal increased amounts of PAIgG, the pattern of PAIgG subclasses, circulating autoantibodies, the specificity of the autoantibodies nor maternal splenectomy could be used to predict the severity of the neonatal thrombocytopenia. In the NAIT group, intracerebral hemorrhage occured in 10% and in the AITP group in 4%.