Abstract
The oncologic safety of allogeneic blood transfusion in ovarian cancer patients is unknow. We sought to determine the prevalence and oncologic safety of perioperative allogeneic blood transfusion during interval cytoreduction surgery among women receiving neoadjuvant chemotherapy for ovarian cancer. We utilized retrospective chart review to identify a cohort of patients undergoing interval cytoreduction at a large academic tertiary referral center. We compared outcomes in patients who were exposed to perioperative blood transfusion compared with patients who were not exposed. Our primary endpoint was progression free survival; our secondary endpoint was overall survival. Baseline clinical characteristics were collected for patients in each group. Sixty-six women were included in the final cohort of women undergoing interval cytoreductive surgery after NACT. A total of 51 women (77%) were exposed to allogeneic perioperative pRBC transfusion. Fifteen women (23%) were not exposed to transfusion. The baseline characteristics were generally well matched. Women who were not exposed to a perioperative blood transfusion were more likely to have a normalized CA125 prior to undergoing cytoreductive surgery. Preoperative hemoglobin concentration was lower in the transfusion group (10.5 g/dLvs 11.5 g/dL, p < 0.009). Perioperative transfusion was not associated with a significant difference in progression free survival (PFS = 7.6 months for transfused, 9.4 months for not transfused; log-rank test p = 0.4617). Similarly, there was no observed difference between groups for overall survival (OS = 23.6 months for transfused, 22.5 months for not transfused; log-rank test p = 0.1723). Women undergoing neoadjuvant chemotherapy for ovarian cancer are at high risk of exposure to blood transfusion at the time of interval cytoreductive surgery. Future studies will continue to evaluate the safety and impact of transfusion on ovarian cancer survival in this at risk population.
Highlights
The oncologic safety of allogeneic blood transfusion in ovarian cancer patients is unknow
We identified a retrospective cohort of patients with ovarian cancer undergoing interval cytoreduction after neoadjuvant chemotherapy (NACT) at our institution over a 3 year period to determine the prevalence of perioperative blood transfusion and explore the impact on overall survival (OS) and progression-free survival (PFS)
Sixty-six women were included in the final cohort of women who undergoing interval cytoreductive surgery after NACT (Fig. 1)
Summary
The oncologic safety of allogeneic blood transfusion in ovarian cancer patients is unknow. We sought to determine the prevalence and oncologic safety of perioperative allogeneic blood transfusion during interval cytoreduction surgery among women receiving neoadjuvant chemotherapy for ovarian cancer. Perioperative blood transfusions have been shown to worsen survival in colorectal, breast and other malignancies [3,4,5,6,7]. These findings have been inconsistently replicated in patients with ovarian cancer [8, 9] but limited research in this area has been published. We identified a retrospective cohort of patients with ovarian cancer undergoing interval cytoreduction after NACT at our institution over a 3 year period to determine the prevalence of perioperative blood transfusion and explore the impact on OS and PFS
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