Abstract
A new modification of the Warthin spirochete staining method was developed to study at the light microscopic level the distribution of spirochetes in gingival tissues of beagle dogs with induced necrotizing ulcerative gingivitis. Spirochetes were present in cellular exudate at ulcerated sites, in edematous epithelium in the vicinity of ulcerations, and in intact sulcular epithelium. They did not appear to penetrate connective tissues via the ulcerations. These observations suggest that, in the etiology of NUG, spirochetes play a role in the initiation of the pathologic process by penetration of the intercellular spaces in the epithelium.
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