Abstract
Necrotizing mucormycosis is a devastating complication of wounds incurred in the setting of military (combat) injuries, natural disasters, burns, or other civilian trauma. Apophysomyces species, Saksenaea species and Lichtheimia (formerly Absidia) species, although uncommon as causes of sinopulmonary mucormycosis, are relatively frequent agents of trauma-related mucormycosis. The pathogenesis of these infections likely involves a complex interaction among organism, impaired innate host defenses, and biofilms related to traumatically implanted foreign materials. Effective management depends upon timely diagnosis, thorough surgical debridement, and early initiation of antifungal therapy.
Highlights
Fungi of the order Mucorales are increasingly recognized as important causes of necrotizing wound infections in the setting of military injuries, burns, natural disaster-related, and other civilian trauma [1,2,3,4,5,6,7]
As the literature on these infections is widely distributed into journals across various disciplines, as well as lay press publications, we summarize the microbiology, pathogenesis, epidemiology, diagnosis, and treatment of wound-associated mucormycosis
Combat-associated wounds complicated by invasive fungal infections (IFIs) injury are associated with natural disaster, that there is a sequence of events that would include
Summary
Fungi of the order Mucorales are increasingly recognized as important causes of necrotizing wound infections in the setting of military (combat) injuries, burns, natural disaster-related, and other civilian trauma [1,2,3,4,5,6,7]. As the literature on these infections is widely distributed into journals across various disciplines, as well as lay press publications, we summarize the microbiology, pathogenesis, epidemiology, diagnosis, and treatment of wound-associated mucormycosis
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