Abstract
Glucagonoma syndrome is a rare disease that is usually associated with an underlying neuroendocrine tumor. Necrolytic Migratory Erythema (NME) has been associated with intestinal malabsorption disorders, hepatic cirrhosis, chronic pancreatitis, inflammatory bowel disease, and non-pancreatic malignancies, but may not always be associated with glucagonoma. In 1979, Mallinson and co-workers coined the term glucagonoma syndrome to describe alpha-cell pancreatic tumors associated with a characteristic erosive skin eruption, termed Necrolytic Migratory Erythema by Wilkinson. NME is characterized by an irregular annular eruption with serpiginous advancing borders, erosion, and crusting, resulting in a scalded appearance. The eruption has a cyclical nature with concurrent lesions at different levels of healing. Here, we report two patients with NME associated with hyperglucagonemia and neuroendocrine tumor.
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