Abstract
Non-coding RNAs have been shown to be important biomarkers and mediators of many different disease entities, including cardiovascular (CV) diseases like atherosclerosis, aneurysms, and valvulopathies. Growing evidence suggests a central role of ncRNAs as regulators of different pathological pathways involved in endothelial dysfunction, cardiovascular inflammation, cell differentiation, and calcification. This review will discuss the role of protein-bound and extracellular vesicular-bound ncRNAs as biomarkers of vascular and valvular diseases, their role as intercellular communicators, and regulators of disease pathways and also highlights possible treatment strategies.
Highlights
Non-coding RNAs (ncRNAs) consists of transfer RNA (tRNA), microRNA (miRNA, or miR), long noncoding RNA (lncRNA), circular RNA (circRNA), and other small RNAs. NcRNA expression has been shown to correlate with several cardiovascular diseases including aortic stenosis
Non-coding RNAs consists of transfer RNA, microRNA, long noncoding RNA, circular RNA, and other small RNAs
NcRNA expression has been shown to correlate with several cardiovascular diseases including aortic stenosis
Summary
Non-coding RNAs (ncRNAs) consists of transfer RNA (tRNA), microRNA (miRNA, or miR), long noncoding RNA (lncRNA), circular RNA (circRNA), and other small RNAs. NcRNA expression has been shown to correlate with several cardiovascular diseases including aortic stenosis. NcRNAs are differentially expressed in monocytes and macrophages isolated from human blood samples from patients with and without high risk for atherosclerosis (Liu et al, 2014c; Yan et al, 2015).
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