Abstract

The rapid evolution of cultivation-independent, multi-omic technologies has increased our appreciation of the complexity, diversity, and vital roles of the human gut microbiome in health and disease, taking it from the realm of dark mystery to one of enlightened fascination. We now know that, in health, the gut microbiome is important for the proper functioning of both digestive and extraintestinal organ systems. It has also become apparent that perturbations of the gut that disrupt critical interactions between host and gut microbes, namely, gut dysbiosis, can cause or promote disease.

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