Abstract
VARIOUS theories have been put forward to explain the excessive calcium output in thyrotoxicosis including an increased metabolism per se1, neutralization of acid products2, direct stimulating catabolic action of thyroxin on bone, and a co-existing hyper-parathyroidism3. For reasons to be given later, all these theories are unsatisfactory. As a result of direct experiments and observations4 on normal subjects and cases of thyrotoxicosis, myxœdema and parathyroid tetany, a new theory has been formulated. It is believed that in thyrotoxicosis, an excessive secretion of thyroxin acts directly on the kidneys, stimulating them to increase their output of calcium. This may be achieved either as a result of the increased metabolism per se or by lowering the renal threshold for calcium.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
