Abstract
The present work is an attempt to explore immunomodulatory activity of some natural products taking into account the major cellular immune reaction, nodulation, in the short horned grasshopper Poekilocerus pictus. It has been shown that two different groups of natural products i.e. quinones, juglone and plumbagin and azadirachtins, neemazal and TN MP-100 inhibit the nodulation reaction against four different species of bacteria, Staphylococcus aureus, Pseudomonas aeruginosa, Escherichia coli, and bacteria isolated from the gut of P. pictus itself (‘self bacteria’),used to artificially infect the grasshopper. Role of eicosanoid in mediation of nodule formation has been shown by studying the effects of eicosanoid inhibitor dexamethasone and rescue experiments using the precursor, arachidonic acid. Significant reduction in the number of nodules by dexamethasone and their restoration by arachidonic acid has shown that eicosanoids function for nodulation in P. pictus. Most interesting result of the present work has been revealed by the fact that all the four natural products inhibit nodule formation in P. pictus, which would lead to impaired immunity in the insect. These results can be exploited in insect pest management by inducing immunodeficiency.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callMore From: Proceedings of the National Academy of Sciences, India Section B: Biological Sciences
Disclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
