Abstract
Polyphenols are naturally occurring compounds found in abundance in fruits and vegetables. Their health-promoting properties and their use in the prevention and treatment of many human diseases, including cancer, have been known for years. Many anti-cancer drugs are derived from these natural compounds. Etoposide, which is a semi-synthetic derivative of podophyllotoxin, a non-alkaloid lignan isolated from the dried roots and rhizomes of Podophyllum peltatum or Podophyllum emodi (Berberidaceae), is an example of such a compound. In this review, we present data on the effects of polyphenols on the anti-cancer activity of etoposide in in vitro and in vivo studies.
Highlights
We described the effect of polyphenols on the activity of etoposide, which is one of the anti-cancer drugs derived from natural compounds
50 mg/kg enhances the tumor reduction and induces apoptosis of BNML cells more efficiently than etoposide alone decreases tumor volume in comparison to mice treated only with etoposide decreases the number of promyelocytes to the normal values occurring in healthy individuals; increases the percentage of the normal precursors of granulocytes and erythrocytes increases the in vivo apoptotic effect of etoposide; increases the oxidative stress induced by etoposide by a decrease in superoxide dismutase (SOD) activity reduces oxidative DNA damage; protects against a decrease in the percentage of myeloid precursors and erythroid nucleated cells caused by etoposide
These results suggest that quercetin may protect bone marrow cells from the harmful effects of chemotherapy based on etoposide
Summary
Many studies indicate the anti-cancer properties of polyphenols [4,5,6] Polyphenols exert their potential in anti-cancer therapy via promoting apoptosis and cell senescence, regulating autophagy, and inhibiting proliferation and migration of cancer cells. It often happens that chemotherapy does not bring the expected results Natural substances, such as polyphenols, have a weaker anti-cancer activity compared to classic chemotherapeutic. Someanti-cancer studies indicate substances, such as polyphenols, have a weaker activity that compared to classic polyphenols are less cytotoxic to normalstudies cells compared cancer cells. Ofbased cancer, but they can contribute to the development of leukemias Their action is on covalent or non-covalent bonding with TopoII, disturbing its functions [9].
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