Abstract
The work is devoted to the study of atrial natriuretic peptide (ANP) and its precursors as one of possible predictors of left ventricular repeated remodeling in patients with ischemic cardiomyopathy (ICMP) in the follow-up (postoperative period). Objects of the study are venous blood and intraoperative samples of right atrial auricle. Precursors of NUP were identified in blood serum by the immuno-fluorescence test. Ultrathin slices of auricle biopsy samples were examined with electronmicroscopy with the use of image processing ImageJ software (program). The concentration of NUP precursors in blood plasma and relation of minimal diameter of secretory granules to maximal one in right auricle cardiomyocytes reflect pathological processes taking place in the myocardium of patients with ICMP. Ratio of minimal and maximal diameters of secretory granules is a predictor of chronic heart failure progressing.
Highlights
The work is devoted to the study of atrial natriuretic peptide (ANP) and its precursors as one of possible predictors of left ventricular repeated remodeling in patients with ischemic cardiomyopathy (ICMP) in the follow-up
Precursors of NUP were identified in blood serum by the immunofluorescence test
Ultrathin slices of auricle biopsy samples were examined with electron- microscopy with the use of image processing ImageJ software
Summary
Гутор С.С.1, Казаков В.А.1, 2, Суходоло И.В.1, Шипулин В.М.2, Бабокин В.Е.2, Огуркова О.Н.2, Андреев С.Л.2, Сафонова А.В.1. Исследование посвящено изучению предсердного натрийуретического пептида (НУП) и его предшественников как одних из возможных предикторов повторного ремоделирования левого желудочка у больных ишемической кардиомиопатией (ИКМП) в отдаленном послеоперационном периоде. Концентрация предшественников НУП в плазме крови и соотношение минимального диаметра секреторных гранул к максимальному в кардиомиоцитах ушка правого предсердия отражает патологические процессы, протекающие в миокарде больных ИКМП. У больных ИКМП развивается ишемическое ремоделирование левого желудочка (ЛЖ), представляющее собой совокупность изменений формы, объема полостей и массы миокарда постинфарктного сердца [1]. Мозговой натрийуретический пептид (BNP) секретируется кардиомиоцитами желудочков сердца, и его концентрация более точно отражает напряжение миокарда в стенке левого желудочка [10].
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