Abstract
ABSTRACTIntroduction: Acute kidney injury (AKI) is a common disorder that causes high healthcare costs. There are limited epidemiological studies of this disorder in low- and middle-income countries. The aim of this study was to describe trends in the age-standardized incidence and mortality rates of AKI in Peru.Methods: We conducted an ecological study based on a secondary data sources of the basic cause of death from healthcare and death records obtained from establishments of the Ministry of Health of Peru for the period 2005-2016. The age-standardized incidence and mortality rates of AKI were described by region and trend effects were estimated by linear regression models.Results:During the period 2005-2016, 26,633 cases of AKI were reported nationwide. The age-standardized incidence rate of AKI per 100,000 people increased by 15.2%, from 10.5 (period 2005-2010) to 12.1 (period 2011-2016). During the period 2005-2016, 6,812 deaths due to AKI were reported, which represented 0.49% of all deaths reported for that period in Peru. The age-standardized mortality rate of AKI per 100,000 people decreased by 11.1%, from 2.7 (period 2005-2010) to 2.4 (period 2011-2016). The greatest incidence and mortality rates were observed in the age group older than 60 years.Conclusions: During the study period, incidence of AKI increased and mortality decreased, with heterogeneous variations among regions.
Highlights
Acute kidney injury (AKI) is a common disorder that causes high healthcare costs
The incidence is higher in the first stage of AKI and the mortality is higher if the patient requires any renal replacement therapy (RRT)
It is estimated that 85% of AKI cases are reported in low- and middle-income countries (LMIC); more than 80% of epidemiology studies on AKI are conducted in high-income countries
Summary
Acute kidney injury (AKI) is a common disorder that causes high healthcare costs. The aim of this study was to describe trends in the age-standardized incidence and mortality rates of AKI in Peru. The age-standardized mortality rate of AKI per 100,000 people decreased by 11.1%, from 2.7 (period 2005–2010) to 2.4 (period 2011–2016). Conclusions: During the study period, incidence of AKI increased and mortality decreased, with heterogeneous variations among regions. Acute kidney injury (AKI) is a common and serious clinical condition deriving from several etiologies and associated with high morbidity, mortality, and healthcare costs [1,2,3,4,5]. It is estimated that 85% of AKI cases are reported in low- and middle-income countries (LMIC); more than 80% of epidemiology studies on AKI are conducted in high-income countries. The etiology of AKI varies across countries, likewise AKI mortality is inversely related to healthcare budget and expenditures of countries . 2,3,6
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