Abstract
Nanopolystyrene particles can cause the adverse effects on environmental organisms. Using Caenorhabditis elegans as an animal model, we found that prolonged exposure to 100 nm nanopolystyrene (≥1 μg/L) could increase the expression of NHR-8, a sterol-sensing nuclear hormone receptor. Mutation of nhr-8 induced a susceptibility to nanopolystyrene toxicity. The increase in NHR-8 activated the response of signaling cascade of DAF-12-FAT-6 to nanopolystyrene, suggesting the alteration in fat metabolism by nanopolystyrene exposure. Moreover, two stress response proteins (UDP-glucuronosyl transferase UGT-18 and P-glycoprotein PGP-6) acted as downstream targets of fatty acyl CoA desaturase FAT-6 to regulate the response to nanopolystyrene. Therefore, nanopolystyrene exposure-induced increase in NHR-8 provided a protective response for nematodes against the potential toxicity of nanopolystyrene.
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