Abstract
“Smart” hydrogels are part of an emerging class of biomaterials that respond to multiple external stimuli. A range of thermoresponsive magnetic hydrogels is currently being developed for on‐demand delivery of biomolecules for a range of biomedical applications, including therapeutic drug delivery, bioimaging, and regenerative engineering. In this review article, we explore different types of magnetic nanoparticles and thermoresponsive polymers used to fabricate these smart nanoengineered hydrogels. We highlight some of the emerging applications of these stimuli‐responsive hydrogels for biomedical applications. Finally, we capture the growing trend of these smart nanoengineered hydrogels and will identify promising new research directions.
Highlights
Stimuli-responsive hydrogels can be designed to respond to changes in external stimuli, such as temperature, pH, light, and ultrasonic frequency.[1,2,3,4,5] Hydrogels that experience physio-chemical changes due to a change in an external stimulus have great potential in the field of noninvasive and remote controlled therapies.[5,6,7,8,9,10] the use of these external stimuli limits the applications of these responsive hydrogels systems to specific tissue regions
A range of thermoresponsive magnetic hydrogels is currently being developed for ondemand delivery of biomolecules for a range of biomedical applications, including therapeutic drug delivery, bioimaging, and regenerative engineering
This review focuses on a subset of thermoresponsive hydrogels that respond to external magnetic fields
Summary
Funding Information Texas Engineering Experiment Station and Texas A&M University Seed Grant (to A.K.G.). Abstract “Smart” hydrogels are part of an emerging class of biomaterials that respond to multiple external stimuli. A range of thermoresponsive magnetic hydrogels is currently being developed for ondemand delivery of biomolecules for a range of biomedical applications, including therapeutic drug delivery, bioimaging, and regenerative engineering. We explore different types of magnetic nanoparticles and thermoresponsive polymers used to fabricate these smart nanoengineered hydrogels. We highlight some of the emerging applications of these stimuliresponsive hydrogels for biomedical applications. We capture the growing trend of these smart nanoengineered hydrogels and will identify promising new research directions. KEYWORDS hydrogels, magnetic nanoparticles, nanocomposites, thermoresponsive, tissue engineering
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