Abstract
AbstractSynthesis of polymer nanocomposite as nanocontainers for doxorubicin (DOX) is carried out at a molar ratio of monomer units of the anionic polysaccharide (sodium hyaluronate) and Ca2+‐ions as a cross‐linking agent equaled to 10/1. Highly water‐soluble white fibrous products can be prepared. The hydrodynamic diameter of nanocompsite (Ca2+/Na‐Hyaluronate) particles is equal to 150 nm. At the same time, diameter of the original sodium hyaluronate (Na‐Hyaluronate) macromolecules is about 300 nm. The interaction between synthesized nanocomposite particles, Ca2+/Na‐Hyaluronate, and DOX accompanied by a new complex formation can be confirmed by means of fluorimetry. Obtained results indicate that the nanocomposite is capable as an immobilizing doxorubicin nanocontainer.
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