Abstract
Nanotechnology is a promising tool for the treatment of cancer. In the past decades, major steps have been made to bring nanotechnology into the clinic in the form of nanoparticle-based drug delivery systems. The great hope of drug delivery systems is to reduce the side effects of chemotherapeutics while simultaneously increasing the efficiency of the therapy. An increased treatment efficiency would greatly benefit the quality of life as well as the life expectancy of cancer patients. However, besides its many advantages, nanomedicines have to face several challenges and hurdles before they can be used for the effective treatment of tumors. Here, we give an overview of the hallmarks of cancer, especially colorectal cancer, and discuss biological barriers as well as how drug delivery systems can be utilized for the effective treatment of tumors and metastases.
Highlights
The development of new technologies allows the improvement of several scientific fields, such as the field of medicine, where essential discoveries have been made by applying knowledge and tools that culminate in the improvement of specialized and personalized therapy strategies [1]
Novel theranostic tools provided by cutting-edge nanotechnology could be helpful in overcoming the challenge faced in the treatment of patients with cancer
This review presents an overview of state-of-the-art nanomedicine-based cancer therapies, with special attention paid to Colorectal cancer (CRC)
Summary
The development of new technologies allows the improvement of several scientific fields, such as the field of medicine, where essential discoveries have been made by applying knowledge and tools that culminate in the improvement of specialized and personalized therapy strategies [1]. Pharmaceutics 2021, 13, 1321 which are applied to assist the health of patients Such improvements are, e.g., sensors and surgical instruments that give detailed information about the location and exact size of a tumor, innovative imaging agents that are specific for a certain tissue, monitoring technologies with improved resolution and sensitivity, and mainly biomaterials with improved targeting characteristics, amongst others [5]. E.g., sensors and surgical instruments that give detailed information about the location and exact size of a tumor, innovative imaging agents that are specific for a certain tissue, monitoring technologies with improved resolution and sensitivity, and mainly biomaterials with improved targeting characteristics, amongst others [5] These medical devices are often used in the diagnosis and treatment of disease and are associated with cell therapy to improve drug delivery, tissue engineering and tissue regeneration. The search for a combination for better treatment efficacy is promoted through the application of innovative molecules, exploring multiple mechanisms of action and maximizing the effectiveness of known drugs, as well as their targeted, accurate and controlled delivery, in order to treat patients more effectively while reducing unwanted adverse effects [8]
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