Abstract
Abstract Bone infections are difficult to treat, resulting usually in severe bone destruction. A variety of bacteria can be the cause of bone infections, including staphylococcus aureus. Osteoclasts, which belong to the macrophage family, are the key cells in bone infections, as they are not well equipped for killing bacteria, but rather enhance their bone resorbing function, when activated in the infection environment. In addition, newly recruited blood monocytes differentiate rather towards osteoclasts, instead of becoming effective macrophages. Silver has been known for centuries for its bactericidal activity. This project investigated the bactericidal effects of 80nm nanosilver particles in E. coli infected human osteoclasts, in vitro. Nano-silver was used at 10μg/ml, which was not toxic to the cells or to the bacteria, when applied directly. However, when bacteria-infected osteoclasts were exposed to nano-silver, intracellular bacterial survival was significantly reduced. Interestingly, ceftriaxone did not have any bactericidal effect on intracellular bacteria in osteoclasts. In conclusion, silver compounds should be considered in the future for the treatment of bacterial bone infections.
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