Abstract
Abstract The temperate bacteriophage N15 is unique among Escherichia coli phages in that its prophage is not integrated into the bacterial chromosome but instead is a linear plasmid molecule with covalently closed ends. Linear plasmids are very unusual in the Enterobacteria and only two others have been reported: phiKO2 in Klebsiella oxytoca (4, 43) and pY54 inYersinia enterocolitica (16). However, such replicons are common in the spirochete genus, Borrelia (1). Here I will summarize the most relevant work on phage N15 with a special emphasis on the mechanism of replication, telomere formation, and control of lysogeny.
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