Abstract
Methods A new series of Nheterocyclic compounds has been derived from benzimidazole and pyrimidine nuclei optimized with the Discovery studio 3.0 software to investigate the interactions between the target compounds and the amino acid residues of Escherichia coli PDF Ni (PDB: ID 1G2A), and then synthesized. Further, all compounds were examined for their antibacterial activities against Gram-positive, S.viridians, and Gram-negative bacterial strains, E. coli, P. mirabilis and K. pneumoniae using the microdilution broth susceptibility test method and subjected to polynomial regression.
Highlights
Global emergence of worsening antibiotic resistance has become a serious problem because of emergence of multi drug resistance (MDR) strains
forced the scientific community to search for new antibiotics
pyrimidine nuclei optimized with the Discovery studio 3.0 software to investigate the interactions between the target compounds
Summary
Global emergence of worsening antibiotic resistance has become a serious problem because of emergence of multi drug resistance (MDR) strains.
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