Abstract
Edgardo Becerra, Karla Padilla, Laura C Berumen and Guadalupe García Alcocer* Author Affiliations Faculty of Chemistry, Autonomous University of Querétaro, University Center, Mexico Received: July 16, 2020 | Published: August 03, 2020 Corresponding author: Guadalupe García Alcocer, Faculty of Chemistry, Autonomous University of Querétaro, University Center, Mexico DOI: 10.26717/BJSTR.2020.29.004776
Highlights
The excess of many chemical substances in humans, such as copper has been reported to induce DNA damage and trigger cancer development [1]
The gathered data indicates that N- acetylcysteine is innocuous at 1000 μM and significantly reduced the DNA damage in human lymphocytes, which were previously treated with Cu2SO4, while N-acetylcysteine exerted an adjuvant effect on the repair of DNA in human lymphocytes
These results indicate the DNA damage in a dose dependent manner (Figure 2)
Summary
The excess of many chemical substances in humans, such as copper has been reported to induce DNA damage and trigger cancer development [1]. The comet assay enables detection of the DNA double-strand breaks (DSBs) and it has been used to evaluate copper genotoxicity caused by oxidative damage in several plants, animals [4,5] and human cells as lymphocytes [6,7]. The DNA damage induced by ROS, can be decreased by the antioxidant action of N-acetylcysteine (NAC). Previous studies have reported the effect of NAC on DNA protection from ROS damage [8]. Ansari, et al reported that NAC protects DNA from oxidative damage in rat intestine [10]
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