Abstract
Wrinkle formation is associated with alteration in the extracellular matrix, collagen and elastic fibers in the dermis of the skin. Cross-linking of collagen is a typical alteration and increases with aging. Glycation (nonenzymatic glycosylation) is the so called Maillard reaction and is a posttranslational modification of proteins resulting from reactions of glucose with amino groups in protein. Collagen cross-linking is also caused by the Maillard reaction.In this study, 10 harb extracts used in the prescriptions for wrinkle removal in ancient Chinese medical literature, were selected and studied for their capacity to collagen cross-linking formation induced by the Maillard reaction. Bukuryou and Byakuren were the most effective inhibitors and Byakuren showed the same effect with aminoguanidine as a positive control. Byakuren also inhibited the formation of fluorescent materials due to the Maillard reaction. These findings may possibly be related to control of the advanced stage of the Maillard reaction.
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