Abstract
The expression of the five main groups of intermediate filaments and their subgroups, especially cytokeratins, was investigated in the guinea pig endolymphatic sac by light microscopy and immunohistochemistry. Immunoreaction for cytokeratin (PKK1, PKK2, PKK3) was found in the epithelial cell layer of the sac. Vimentin was seen to stain the epithelial cell layer as well as subepithelial tissue. These findings suggest that the cytokeratins are involved in the inner ear fluid transporting mechanism. The co-expression of cytokeratin and vimentin may be closely related to the dynamic properties of the endolymphatic sac which regulate inner ear fluid homeostasis.
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