Abstract
We previously reported three activated and two suppressed genes detected by cDNA microarrays in peripheral lymphocytes from chronic hepatitis C (C-CH) patients. In this report, we investigated whether they could predict the outcome of interferon (IFN) treatment. Ten C-CH patients were treated by β-interferon for 26 weeks (with some variations), and sustained virological response (SVR) was achieved in six. Three activated genes: migration inhibitory factor-related protein 14 (MRP-14), interleukin (IL)-8 precursor, and puromycin-sensitive aminopeptidase (PSA), were detected in 33%, 33% and 67%, respectively in SVR patients, and in 100%, 75% and 50%, respectively in non-SVR patients. Two suppressed genes, platelet basic protein (PBP). precursor and monoamine oxidase (MAO-A), were detected in 67% and 50%, respectively in SVR patients, but in 75% and 50%, respectively in non-SVR patients. Since the statistical analysis did not show significance in this small size pilot study, further study will be needed to prove the hypothesis that these genes would predict non-SVR in IFN teatment.
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