Abstract
The effect of emedastine difumarate on nasal obstruction was examined in 21 patients (8 males and 13 females, average age: 26.3 years) with perennial nasal allergy. The patients received 2 mg of emedastine difumarate twice a day for one or two weeks. Objective measurement of nasal obstruction was performed by active anterior rhinomanometry using nozzle before and after treatment. Nasal resistance at the point of ΔP100Pa in inspiration was calculated for the analysis. For the statistical analysis the paired t test was applied.The decrease in the subjective symptom score was significant. However, there was a small but ot statistically significant decrease [0.416 Pa/(ml/sec)→0.360 Pa/(ml/sec)] in nasal resistance inn all cases. A significant decrease [0.500 Pa/(ml/sec)→0.307 Pa/(ml/sec), p < 0.05] in nasal resistance was noted in patients who had complained of slight nasal obstruction.Our findings confirm the efficacy of emedastine difumarOate in the treatment of nasal obstruction in allergic rhinitis.
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