Abstract
When cows were administered orally with CCl4, severe acute liver damage was found in them on the 3rd to 4th day after administration and cured by the 23rd to 26th day. There were an increase in serum GOT·γ-GT activities, in free fatty acid (FFA)·Etriglyceride (TG)·Ebilirubin·γ-globulin level in serum, in TG·FFA·cholesterol (Chol) content and in hexokinase activity in the liver, and a decrease in pospholipid (PL)·albumin (Al)·EA: G ratio level in serum, in glycogen (Gly) content and in glucose-6-phosphatase activity in the liver. The BSP test was highly positive and fatty infiltration into hepatic cells was recognized.Six cows with acute liver damage were injected intravenously with about 100mg/kg of 2-mercaptopropionyl-glycine (2-MPG) daily for 4 days beginning with the 4th day after CCl4 administration. Rapid recovery was seen in TG·FFA·Gly contents and glucose-6-phosphatase activity in the liver, in serum GOT·SDH·ALP activities, in results of the BSP test, in serum PL·TG·A: Gratio· bilirubin level, and in fatty infiltration of hepatic cells. From these results, 2-MPG appears to act on the enzymatic system as an SH-compound and have liver-protecting effects as SH-group supplement.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callMore From: Journal of the Japan Veterinary Medical Association
Disclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
