Abstract

A tumor stimulates the growth of small blood vessels for feeding itself. Tumor-derived small blood vessels are an intrinsic part of the tumor's development and progression. Radiographic depiction of tumor-derived small vessels is a useful tool for a basic medical study of malignant tumors. A high-resolution X-ray imaging system with a spatial resolution in the micrometer range was developed at SPring-8 for the depiction of newly formed blood vessels in animal models of cancer. The imaging system is composed of two types of detectors. One is an X-ray indirect-conversion type detector, which is a fluorescent-screen optical-lens coupling system using a high-sensitivity HARPICON pickup tube. The other type is an X-ray direct-conversion type detector, which incorporates an X-ray direct-sensing SATICON pickup tube. Small tumor blood vessels with diameters of around 15μm were observed after injecting a contrast material to the artery in experiments using small animals.

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