Abstract
A wearable glucose sensor for tear sugar measurement was fabricated and evaluated. The sensor was constructed by immobilizing glucose oxidase onto a flexible oxygen electrode, which was fabricated using "Soft-MEMS" techniques onto a functional polymer membrane. Linear relationship between glucose concentration and output current was obtained in a range of 0.049 to 1.37 mmol/l, with a correlation coefficient of 0.998. In addition to characteristics evaluation, the sensor was utilized to tear glucose measurement of a Japan white rabbit. The change of tear sugar induced by oral-administration of glucose was monitored as a current change of the wearable glucose sensor attached on the eye site. In this investigation, the tear glucose level varied from 0.3 to 0.93 mmol/l.
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