Abstract
The differentiation of the subglottic mucosa in human fetuses has been studied only by light microscopy. We observed for the first time the development of human subglottic mucosa from the 8th to the 21st week of gestation by scanning as well as transmission electron microscopies, and could obtain the following conclusions:1. Ciliated cells and goblet cells appeared at the 12th week of gestation that was similar to the previous reports, and the detailed cytodifferentiation of both cells could be observed.2. We could demonstrate for the first time that primary cilia appeared in the subglottic mucosa at the 10th week of gestation. Among these primary cilia, very long ones were observed and were supposed to be the grown forms of short primary cilia.3. Glycogen granules in non-ciliated cells were observed in parallel with the cell differentiation, so they were seemed to be the source of energy necessary for the cell differentiation.
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