Abstract
Techniques of membrane plasma separation consist of microfiltration that is a pressure-driven membrane process for separation of plasma from blood in therapeutic and donor apheresis. Filtration characteristics in plasma separation cannot be explained by the well-known ultrafiltration theory. Elucidation of filtration characteristics and mechanism of fouling is required to develop a highly efficient filter for plasma separation.In this review, filtration characteristics of a small-sized rotating filter for plasma separation composed of flat polycarbonate and Nylon membranes and a plasma filter composed of microporous glass (MPG) membranes were elucidated. The rotating filter was capable of producing higher wall shear rates caused by the formation of Taylo vortices without significant increases in blood-side pressure drop. The MPG membranes are resistant to chemicals, heating and wear, and these membranes have the advantages of the absence of hemolysis and excellent filtration characteristics because of their limited distribution of pore diameter.
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