Abstract
The mechanism of diethylhexyl phthalate (DEHP) leaching from a polyvinyl chloride (PVC) container or an administration set into the intravenous alprostadil solution was investigated. After stored in the PVC bag for 24 hours at initial alprostadil concentration of 0.50μg/ ml, the released amount of DEHP was 20.5μg/ ml. The additives effecting on the DEHP leaching in the alprostadil injection were lecithin and soybean oil. It was estimated that DEHP leaching from the PVC membrane occurred through mechanisms of emulsification with lecithin and dissolution into soybean oil particle in the intravenous alprostadil solution.
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