ポリ塩化ビニル膜へのミコナゾールの収着速度に与えるポリオキシエチレン化ヒマシ油とｐＨの影響

Abstract

We investigated the effect of pH and polyoxyethylated castor oil which was used as a solubilizing agent on the sorption rate of miconazole from the buffer solotions to the intravenous administration sets. The leaching of diethylhexyl phthalate which was used as a plasticizer formulated in the preparation of polyvinyl chloride membrane from the intravenous administration sets into the polyoxyethylated caster oil solutions was obverved. The leaching rate was not influenced by the pH in the solutions. Whereas the sorption rate of miconazole was influenced by the polyoxyethylated castor oil concentration and the pH in the solution.When polyoxyethylated castor oil was not added to the solution, the pH profile of the miconazole sorption rate was pH4. 0<pH5. 0<pH6. O. On the other hand, when polyoxyethylated castor oil was added, this rate was pH4.0<pH7.0<pH5.0 and pH 6.0. It was estimated that the sorption rate of miconazole was dependent on the concentrations of the miconazole ionized form in the aqueous phase, the partition rate from the miconazole molecular form in the micelle to the free molecular form in the aqueous phase, and the partition rate from the free molecular form in the aqueous phase to the molecular form in the organic phase.