Abstract
The title compound was synthesized by electrophilic cyanation of commercially available (R)-4-chloro-α-methylbenzylamine with cyanogen bromide in diethyl ether, and isolated as a yellow oil in 84% yield. It was characterized by 1H and 13C{1H] NMR, IR, HRMS, and specific rotation measurements.
Highlights
Cyanamides attractive building blocks for the of nitrogen-richCyanamidesare are attractive building blocks for construction the construction of nitrogenmolecules such as amidines, guanidines, or ureas [1,2,3].the cyanamide moiety rich molecules such as amidines, guanidines, or ureas [1,2,3]
We report the synthesis and electrophilic cyanide source [1,2,3,8]
We report the synthesis characterization of N-[(1R)-1-(4-chlorophenyl)ethyl]-cyanamide, a novela chiral and characterization of N-[(1R)-1-(4-chlorophenyl)ethyl]-cyanamide, novel cyanamide chiral cyanthat could have potential application as an advanced intermediate in asymmetric synthesis
Summary
Cyanamidesare are attractive building blocks for construction the construction of nitrogenmolecules such as amidines, guanidines, or ureas [1,2,3]. The cyanamide moiety rich molecules such as amidines, guanidines, or ureas [1,2,3]. The cyanamide ismoiety presentisinpresent a number of biologically active molecules, such as the cathepsin. K protease in a number of biologically active molecules, such as the cathepsin K and the type 4 phosphodiesterase inhibitors Ainhibitors [4] and B A [5],[4]. Respectively, or the insecticides protease and the type 4 phosphodiesterase and B [5], respectively, or the thiacloprid [6] and sulfoxaflor (D).
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