Abstract
Myocardial hypertrophy reduces transmural variation in mitochondrial function.
Highlights
Reviewed by: Corrado Poggesi, University of Florence, Italy Thomas M
The recent study by Kindo et al (2012) in this journal investigated whether transmural variation in mitochondrial function precedes heart failure
One of the important findings was that in the sham animals, the sub-epicardial tissue had ∼55% greater mitochondrial respiratory chain complex IV activity than the sub-endocardium
Summary
Reviewed by: Corrado Poggesi, University of Florence, Italy Thomas M. A commentary on Pressure overload-induced mild cardiac hypertrophy reduces left ventricular transmural differences in mitochondrial respiratory chain activity and increases oxidative stress by Kindo, M., Gerelli, S., Bouitbir, J., Charles, A. There is growing evidence that some cellular properties of mammalian hearts are transmurally heterogeneous, varying systematically from the inner (sub-endocardium) to the outer (subepicardium) region of the left ventricular wall.
Sign-in/Register to view highlights & summary Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
