Abstract

of glucose concentration on angiotensin 11-induced hypertrophy of proximal tubular cells in culture. Biochem Biophys Res Commun 1991; 176: 902-909 14. Flyvbjerg A, Bornfeldt KE, Marshall SM, Arnqvist HJ, Orskov H. Kidney IGF-I mRNA in initial renal hypertrophy in experimental diabetes in rats. Diabetologia 1990; 33: 334-338 15. Wolf G, Sharma K, Chen Y, Ericksen M, Ziyadeh FN. High glucose-induced proliferation in mesangial cells is reversed by autocrine TGF-0. Kidney Int 1992; 42: 647-656 16. Crowley ST, Brownlee M, Edelstein D et al. Effects of nonenzymatic glycosylation of mesangial matrix on proliferation of mesangial cells. Diabetes 1991; 40: 540-547 17. Nakamura T, Fukui M, Ebihara I et al. mRNA expression of growth factors in glomeruli from diabetic rats. Diabetes 1993; 42: 450-456 18. Ayo SH, Radnik RA, Glass WF et al. Increased extracellular matrix synthesis and mRNA in mesangial cells grown in highglucose medium. Am J Physiol 1991; 260: F185-F191 19. Ziyadeh FN, Sharma K, Ericksen M, Wolf G. Stimulation of collagen gene expression and protein synthesis in murine mesangial cells by high glucose is mediated by autocrine activation of transforming growth factor-/?. J Clin Invest 1994; 93: 536-542 Nephrol Dial Transplant 1995: Editorial Comments

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