Abstract
Activating mutations that lead to constitutive growth and survival signals are one of the major drivers for the development of cancer. By whole genome sequencing, we discovered the highly recurring MYD88 L265P (MYD88L265P) mutation in >90% of WM patients.[Treon et al, N Engl J Med., 2012] Hematopoietic cell kinase (HCK) is a member of the SRC family tyrosine kinases (SFKs), and is normally expressed in cells of myeloid and B-lymphocyte lineages. In B-lymphocyte lineages, HCK is commonly expressed in earlier B-cell progenitors and is downregulated in mature B-cells.
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