Abstract
Amyotrophic lateral sclerosis (ALS) is also known as gradual freezing disease, which is a fatal neurodegenerative disease...
Highlights
Amyotrophic lateral sclerosis (ALS) is known as gradual freezing disease, which is a fatal neurodegenerative disease
This review summarizes the recents findings about the function of dynactin subunit 1, valosin containing protein, sequestosome 1, optineurin, TANK binding kinase 1, C9orf72-SMCR8 complex subunit and alsin Rho guanine nucleotide exchange factor which may partly explain the possible reason of autophagy dysregulation in amyotrophic lateral sclerosis (ALS)
ALS is divided into sporadic ALS and familial ALS, and sALS accounts for about 90% to 95% of all cases [3]
Summary
Amyotrophic lateral sclerosis (ALS) is known as gradual freezing disease, which is a fatal neurodegenerative disease. As an important part of intracellular transport, can clear protein aggregates. It can be dysregulated by several ALS-related gene mutations which will cause motor neuron degeneration.
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