Abstract
The mutagenicity of 2-hydroxyalkyl- N-nitrosothiazolidines was tested using Salmonella typhimurium strains TA98 and TA100. The N-nitrosothiazolidines tested were unsubstituted N-nitrosothiazolidine (NT), N-nitrosothiazolidine-4-carboxylic acid (NTC), 2-hydroxymethyl- N-nitrosothiazolidine (HMNT), 2-(1,2,3,4-tetrahydroxybutyl)- N-nitrosothiazolidine, 2-(1,2,3,4-tetrahydroxypentyl)- N-nitrosothiazolidine, 2-(1,2,3,4,5-pentahydroxypentyl)- N-nitrosothiazolidine (PHPNT) and 2-(1,2,3,4,5-pentahydroxypentyl)- N-nitrosothiazolidine-4-carboxylic acid. Among the N-nitrosothiazolidines tested, only HMNT and PHPNT exhibited clear dose-response mutagenicity toward strain TA100 with or without metabolic activation. None of the 2-hydroxyalkyl- N-nitrosothiazolidines were mutagenic to strain TA98. NT exhibited much stronger mutagenicity than either HMNT or PHPNT. Mutagenic activities of NT and PHPNT were eliminated by carboxyl substitution in the position α to the N-nitroso group.
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